Tumor-infiltrating CD8+ T cells in ALK-positive lung cancer are functionally impaired despite the absence of PD-L1 on tumor cells

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Ángel García-Díaz, Daniel Sanghoon Shin, Blanca Homet Moreno et al. · Cell Reports · 2017 · 1.9K citations · Full text

Life Sciences, Immunology, Oncology +17

Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

Mojgan Ahmadzadeh, Laura A. Johnson, Bianca Heemskerk et al. · Blood · 2009 · 1.8K citations · Full text

Medicine, Immunology, Oncology +12

<i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis

Justin F. Gainor, Alice T. Shaw, Lecia V. Sequist et al. · Clinical Cancer Research · 2016 · 1.2K citations · Full text

Medicine, Oncology, Pharmacology +17

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

Alena Gros, Paul F. Robbins, Xin Yao et al. · Journal of Clinical Investigation · 2014 · 1.1K citations · Full text

Life Sciences, Immunology, Oncology +17

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Michał Marzec, Qian Zhang, Ami Goradia et al. · Proceedings of the National Academy of Sciences · 2008 · 723 citations · Full text

Medicine, Cancer Biology, Oncology +16