Concepedia

Screening embryos for polygenic conditions and traits: ethical considerations for an emerging technology

Gabriel Lázaro‐Muñoz, Stacey Pereira, Shai Carmi, Todd Lencz

Genetics in Medicine · 2020 · 68 citations · 15 references

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References

15

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Amit V. Khera, Mark Chaffin, Krishna G. Aragam et al. · Nature Genetics · 2018 · 3.1K citations

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Analysis of polygenic risk score usage and performance in diverse human populations

Laramie E. Duncan, Hanyang Shen, Bizu Gelaye et al. · Nature Communications · 2019 · 1.1K citations · Full text

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Variable prediction accuracy of polygenic scores within an ancestry group

Hakhamanesh Mostafavi, Arbel Harpak, Ipsita Agarwal et al. · eLife · 2020 · 488 citations · Full text

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Screening Human Embryos for Polygenic Traits Has Limited Utility

Ehud Karavani, Or Zuk, Danny Zeevi et al. · Cell · 2019 · 118 citations · Full text

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In defence of Procreative Beneficence

Julian Savulescu · Journal of Medical Ethics · 2007 · 104 citations · Full text

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