Journal of Medicinal Chemistry · 2020 · 38 citations · 41 references
MedicineMedicinal ChemistryOncologyCancer PharmacologyChemotherapyDrug DiscoveryCancer GlycobiologyGlycan StructureTopoisomerase InhibitorsAnticancer ActivityAnticancer ChemotherapyBiological Activity FeaturesDouble-strand Dna BreaksGlycan-based Cancer TherapeuticsHistone EvictionTopoisomerase Ii FunctionTopoisomerase-mediated Dna Breaks
-dimethylamine at the reducing sugar prove that are more cytotoxic than their nonmethylated counterparts. This structural information will support further development of novel anthracycline variants with improved anticancer activity.
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A clinicopathologic analysis of adriamycin cardiotoxicity
Edward A. Lefrak, Jan Piťha, Sidney Rosenheim et al. · Cancer · 1973 · 1.6K citations
Medicine, Cardiology, Pharmacology +16
Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin
Loren Dean Williams, Giovanni Ughetto, G. A. VAN DER MAREL et al. · Biochemistry · 1990 · 587 citations
Medicine, Oncology, Pharmacology +7
The anthracyclines: will we ever find a better doxorubicin?
PubMed · 1992 · 559 citations
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