Concepedia

Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents

Yan Qu, Chong Zhang, Xin Ma, Yunhui Gao, Jing Liu, Liqiang Wu

Bioorganic & Medicinal Chemistry · 2020 · 24 citations · 16 references

DOI

Concepts

References

16

NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

David Siegel, Daniel L. Gustafson, Donna L. Dehn et al. · Molecular Pharmacology · 2004 · 448 citations

, , +17

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

Sukhendu Maiti, Nayoung Park, Ji Hye Han et al. · Journal of the American Chemical Society · 2013 · 326 citations

, , +17

High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

Thierry Cresteil, Anil K. Jaiswal · Biochemical Pharmacology · 1991 · 201 citations

, , +11

Clinical implications of high NQO1 expression in breast cancers

Yang� Yang, Yan Zhang, Qunying Wu et al. · Journal of Experimental & Clinical Cancer Research · 2014 · 186 citations · Full text

, , +17

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

Peilian Liu, Jiangsheng Xu, Donghang Yan et al. · Chemical Communications · 2015 · 93 citations

, , +17