Concepedia

Discovery of novel artemisinin-sulfonamide hybrids as potential carbonic anhydrase IX inhibitors with improved antiproliferative activities

Ran An, Bin Lin, Shuang Zhao, Chun Cao, Yuanxin Wang, Xue Cheng, Yichuang Liu, Mengbi Guo, Hang Xu, Yitong Wang,

Bioorganic Chemistry · 2020 · 21 citations · 30 references

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsChemical Library DesignEnzyme InhibitionLigand-based DesignMedicinal PlantsNatural Product-based Drug DesignStructure-activity Relationship AnalysisAntiproliferative AgentsAntiproliferative Drug ActionBioactive Compound LibrariesCarbonic Anhydrase FunctionCarbonic Anhydrase InhibitorsMedicinal Chemistry ApplicationsStructure - Activity Relationship Optimization

References

30

Carbonic anhydrase inhibitors

Claudiu T. Supuran, Andrea Scozzafava, Angela Casini · Medicinal Research Reviews · 2002 · 1.4K citations

Medicine, Biochemistry, Pharmacology +12

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Charles C. Wykoff, Nigel Beasley, Peter H. Watson et al. · PubMed · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +17

Esterase Activities of Human Carbonic Anhydrases B and C

Jacob A. Verpoorte, S. N. Mehta, John T. Edsall · Journal of Biological Chemistry · 1967 · 1K citations · Full text

Life Sciences, Biochemistry, Catalysis +14

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Johanna Chiche, Karine Ilc, Julie Laferrière et al. · Cancer Research · 2008 · 746 citations

Medicine, Cancer Biology, Oncology +17

Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH

Eliška Švastová, Alžbeta Hulı́ková, Monika Rafajová et al. · FEBS Letters · 2004 · 707 citations · Full text

Medicine, Biochemistry, Oncology +17