ATAC-Seq Reveals an <i>Isl1</i> Enhancer That Regulates Sinoatrial Node Development and Function

Abstract

(1) PCs have distinct regions of accessible chromatin that correlate with their gene expression profile and contain novel SAN enhancers, (2) <i>cis</i>-regulation of <i>Isl1</i> specifically in the SAN depends upon a conserved SAN enhancer that regulates PC development and SAN function, and (3) a corresponding human <i>ISL1</i> enhancer may regulate human SAN function.