Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth

Structural determinants of water permeation through aquaporin-1

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Natural Sciences, Biochemistry, Ion Channel Biophysics +11

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Elizabeth E. Spangenberg, Paul Severson, Lindsay A. Hohsfield et al. · Nature Communications · 2019 · 998 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial

Michael A. Davies, Philippe Saïag, Caroline Robert et al. · The Lancet Oncology · 2017 · 775 citations · Full text

Medicine, Oncology, Pharmacology +12

The Gut Microbiome Modulates Colon Tumorigenesis

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Life Sciences, Microbiology, Oncology +17

Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

Samira Saadoun, Marios C. Papadopoulos, Mariko Hara‐Chikuma et al. · Nature · 2005 · 727 citations

Life Sciences, Genetics, Molecular Genetics +14