IDO-inhibitor potentiated immunogenic chemotherapy abolishes primary tumor growth and eradicates metastatic lesions by targeting distinct compartments within tumor microenvironment

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Michel Obéid, Antoine Tesnière, François Ghiringhelli et al. · Nature Medicine · 2006 · 3.1K citations

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Thorsten R. Mempel, Sarah E. Henrickson, Ulrich H. von Andrian · Nature · 2004 · 1.7K citations

Life Sciences, Cell Biology, Immunology +17

Up-Regulation of PD-L1, IDO, and T _regs in the Melanoma Tumor Microenvironment Is Driven by CD8 ⁺ T Cells

Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha et al. · Science Translational Medicine · 2013 · 1.7K citations · Full text

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An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Joshua D. Mezrich, John H. Fechner, Xiaoji Zhang et al. · The Journal of Immunology · 2010 · 1.6K citations · Full text

Life Sciences, Immunology, Pharmacology +15