Synthesis of 2‐Aryl‐2‐hydroxyethyl Dithiocarbamates via Regioselective Addition of Tetraalkylthiuram Disulfides to Styrenes under Transition‐Metal‐Free Conditions

Abstract

Abstract This paper describes a method for the synthesis of 2‐aryl‐2‐hydroxyethyl dithiocarbamates via difunctionalization of alkenes involving C−S and C−O bonds formation with tetraalkylthiuram disulfides as the functional reagents. The reaction proceeded well under transition‐metal‐free conditions and afforded up to 88% yield of the desired products. Numerous useful functional groups were tolerated under the reaction conditions. This methodology provides a direct approach to β‐hydroxy dithiocarbamates, featuring readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis. magnified image