Fatal Lymphocytic Cardiac Damage in Coronavirus Disease 2019 (COVID-19): Autopsy Reveals a Ferroptosis Signature

Abstract

The findings in this case are unique as this is the first report on accumulated oxidized phospholipids (or their breakdown products) in myocardial and renal tissue in COVID-19. This highlights ferroptosis, proposed to detrimentally contribute to some forms of ischaemia-reperfusion injury, as a detrimental factor in COVID-19 cardiac damage and multiple organ failure.