Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Forsk) is on the rise despite the much publicized associated deleterious health effects. How chemicals present in khat, affect various physiological and biochemical processes requires further scrutiny. A clear understanding of these processes will provide an avenue for countering khat-driven negative effects using appropriate pharmacological and/or nutritional interventions. AIM OF THE STUDY: ), a potent antioxidant and anti-inflammatory, in modulating any negative effects due to khat exposure. METHODOLOGY: and 1500 mg/kg b/w of khat extract. The experiment was conducted for 90 days after which samples were collected for physiological and biochemical analyses. RESULTS: -driven normalization of GSH and TNF-α levels, indicating a protective effect from khat-driven oxidative stress and inflammation respectively. CONCLUSION: may be useful in nullifying khat-driven deleterious events among chronic khat users.