Direct Chiral ¹⁹F NMR Analysis of Fluorine-Containing Analytes and Its Application to Simultaneous Chiral Analysis

Abstract

We have demonstrated the efficient chiral analysis of fluorine-containing compounds by 19F NMR spectroscopy. The highly sensitive fluorine nucleus allowed chiral analysis of complex mixtures and even asymmetric reaction mixtures of multisubstrates. A single 19F NMR experiment was sufficient to determine the enantiomeric excesses and yields of the five products simultaneously.