Photoactivated Nanosheets Accelerate Nucleus Access of Cisplatin for Drug‐Resistant Cancer Therapy

Abstract

Abstract Non‐small cell lung cancer (NSCLC) is a primary threat to human health. Cisplatin is always in first‐line treatment of NSCLC; however, cisplatin resistance restricts the application in the clinic. Herein, an innovative 2D platinum delivery platform based on manganese dioxide nanosheet is presented to overcome cisplatin‐resistance and enhance theranostic efficacy in NSCLC. The photo‐induced hyperthermia of nanosheets can inhibit Pt drug efflux from the multidrug resistance‐associated protein (MRP1) repression. Then the intracellular l ‐Glutathione (GSH) consumed by MnO 2 nanosheets can reduce the generation of GSH‐Pt complex. Working along both lines accelerates access to the nucleus for cisplatin. Moreover, chemo‐photothermal synergistic therapy of Pt nanosheets significantly enhances therapeutic efficacy in vitro and in vivo. In addition, nanosheets can exert an on‐demand activable magnetic resonance imaging contrast effect to monitor Pt drug release. For the first time, a promising photoactivated 2D vector is provided to overcome cisplatin resistance in NSCLC therapy.