Concepedia

KLF5-Modulated lncRNA NEAT1 Contributes to Tumorigenesis by Acting as a Scaffold for BRG1 to Silence GADD45A in Gastric Cancer

Pei Ma, Yutian Pan, Fan Yang, Yuan Fang, Wei-Tao Liu, Chenhui Zhao, Tao Yu, Mengyan Xie, Xingming Jing, Xi Wu,

Molecular Therapy — Nucleic Acids · 2020 · 39 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

. Taken together, our data support the importance of NEAT1 in promoting GC tumorigenesis and indicate that NEAT1 might be a diagnostic and therapeutic target in GC.

References

27

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

, , +16

Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

Linda J Kuo, Li‐Xi Yang · PubMed · 2008 · 1.2K citations

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The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

John R. Prensner, Matthew K. Iyer, Anirban Sahu et al. · Nature Genetics · 2013 · 683 citations · Full text

, , +10

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

Yanying Wang, Lei He, Ying Du et al. · Cell stem cell · 2015 · 654 citations · Full text

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p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

Carmen Adriaens, Laura Standaert, Jasmine Barra et al. · Nature Medicine · 2016 · 475 citations

, , +16