Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Liming Sun, Huayi Wang, Zhigao Wang et al. · Cell · 2012 · 2.6K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

Henning Walczak, Robert E. Miller, K. Ariail et al. · Nature Medicine · 1999 · 2.5K citations

Inflammation, Anti-inflammatory, Medicine +9

Safety and antitumor activity of recombinant soluble Apo2 ligand

Avi Ashkenazi, Roger Pai, Sharon Fong et al. · Journal of Clinical Investigation · 1999 · 2.2K citations · Full text

Apo2l Mrna, Medicinal Chemistry, Apo2l Treatment +13

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Sudan He, Lai Wang, Lin Miao et al. · Cell · 2009 · 2.2K citations

Inflammation, Cytokine, Signal Transduction +11

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Huayi Wang, Liming Sun, Lijing Su et al. · Molecular Cell · 2014 · 1.5K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +9