Electrochemical Decarboxylative <i>N</i>-Alkylation of Heterocycles

Abstract

An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the <i>N</i>-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.