An Overview on the Chemical <i>N</i>‐Functionalization of Sugars and Formation of <i>N</i>‐Glycosides

Abstract

Its even more than a centennial that the systematic researches of chemical alteration of sugars have been advancing. Out of all the interest in the field of N ‐glycoside has assembled pace over the past few years. Therefore, N ‐functionalization of sugar is one of the most fundamental modifications along with other group like azide, amide etc also play a remarkable role in the field of glycoscience. Different approaches to access structurally modified N ‐glycosides in carbohydrate derivatives are reviewed. The goal of this review is to provide an overview of different way of N ‐functionalization of amino sugar and induction of nitrogen scaffolds for the synthesis of various orthogonal protective groups of the N ‐glycoside. The N ‐functionalization of sugars designate as follows: (a) glycosylamine, (b) glycosyl azide, and (c) introduction of N ‐functionality to the sugar for formation of N ‐glycosides. This is the first review focus on N ‐functionalization of sugars which will be a future scope that influence the readers to work in this area further.