Concepedia

Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

Brian Jermain, Patrick O. Hanafin, Yanguang Cao, A. Lifschitz, Carlos Lanusse, Gauri G. Rao

Journal of Pharmaceutical Sciences · 2020 · 45 citations · 18 references

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References

18

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Wenhui Li, Michael J. Moore, Natalya Vasilieva et al. · Nature · 2003 · 6.2K citations · Full text

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Inge Hamming, Wim Timens, MLC Bulthuis et al. · The Journal of Pathology · 2004 · 5.9K citations · Full text

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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly, Julian Druce, Mike Catton et al. · Antiviral Research · 2020 · 2.2K citations · Full text

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff, Haran Sivakumaran, Steven M. Heaton et al. · Biochemical Journal · 2012 · 668 citations · Full text

, , +19

Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development

HM Jones, K Rowland‐Yeo · CPT Pharmacometrics & Systems Pharmacology · 2013 · 561 citations · Full text