Concepedia

Association between SARS-CoV-2 Neutralizing Antibodies and Commercial Serological Assays

Mei San Tang, James Brett Case, Caroline E Franks, Rita E. Chen, Neil W. Anderson, Jeffrey P. Henderson, Michael Diamond, Ann M. Gronowski, Christopher W Farnsworth

Clinical Chemistry · 2020 · 129 citations · 18 references

DOIFull text

Open access

Abstract

COVID-19 patients generate an antibody response to multiple viral proteins such that the calibrator ratios on the Roche, Abbott, and EUROIMMUN assays are all associated with SARS-CoV-2 neutralization. Nevertheless, commercial serological assays have poor NPA for SARS-CoV-2 neutralization, making them imperfect proxies for neutralization.

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