Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism

Markus Stoffel, Stephen A. Duncan · Proceedings of the National Academy of Sciences · 1997 · 411 citations

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

Tao Gao, Brian D. McKenna, Changhong Li et al. · Cell Metabolism · 2014 · 401 citations · Full text

Signal Transduction, Cell Signaling, Cell Interaction +8

Insulin Secretion Depends on Intra-islet Glucagon Signaling

Berit Svendsen, Olav Larsen, M Gabe et al. · Cell Reports · 2018 · 335 citations · Full text

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Sophie Bauer, Charlotte Wennberg Huldt, Kajsa P. Kanebratt et al. · Scientific Reports · 2017 · 260 citations · Full text

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

Chunyan Gu, Gretchen H. Stein, Ning Pan et al. · Cell Metabolism · 2010 · 247 citations · Full text

Developmental Biology, Maintain Functional Maturity, Pancreatic Cancer +7