Chemical Science · 2020 · 111 citations · 27 references
PharmacyPharmacologyDrug DesignDrug DiscoveryStructural BiologyDrug Targeting StrategiesLigand BindingTargeting LigandsCysteine-targeted InhibitorsZinc Binding ProteinsZinc Finger Domains
protease. We propose combining disulfiram/ebselen with broad-spectrum antivirals/drugs to target different conserved domains acting at various stages of the virus life cycle to synergistically inhibit SARS-CoV-2 replication and reduce the emergence of drug resistance.
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