Theranostics · 2020 · 289 citations · 45 references
MedicineOncologyPharmacologyCancer PharmacologyMolecular Cell BiologyMolecular OncologyApoptosis In CancerApoptosis PharmacologyBcl-2 Family ProteinsCancer Cell SignalingCancer ProteomicsReactive Oxygen SpeciesAntioxidant PropertiesApoptosis Signaling In CancerApoptosis TargetingCancer Cell ApoptosisCell Death In CancerOxidative Stress In CancerOxidative Stress InjuryReactive Oxygen Species Generation
Our studies have uncovered a potential Celastrol-interacting protein Prdx2 and a ROS-dependent mechanism of its action. The findings also highlight Prdx2 as a potential target for the treatment of gastric cancer.
45