Theranostics · 2020 · 28 citations · 36 references
Life SciencesMolecular BiologyOncologyApoptosisMolecular OncologySignal TransductionApoptosis In CancerApoptosis RegulationApoptotic Signal TransductionApoptotic SignalingDeath ReceptorsHepatocellular CarcinomaHepatocellular Carcinoma PathogenesisNf-κb SignalingPro-apoptotic ProteinsTnfr1 SignalingTumor Necrosis Factor Receptor 1 SignalingTumor Necrosis Factor Receptor SignalingTumor Necrosis Factor-mediated ApoptosisUbiquitin-mediated Degradation
Our findings illustrate a crucial role for HRG in suppressing HCC via inclining TNFR1 to a pro-apoptotic cellular phenotype. Restoring HRG expression in HCC tissues might be a promising pharmacological approach to blocking tumor progression by shifting cellular fate from cell survival to apoptosis.
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