Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Chunli Yu, Yan Chen, Gary W. Cline, +11

Journal of Biological Chemistry

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Rachel J. Perry, Liang Peng, Natasha A. Barry, +7

Nature

Metabolic SyndromePhysiologyMicrobiotaMetabolic RegulationMetabolism +5

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

Rachel J. Perry, João Paulo Camporez, Romy Kursawe, +17

Cell

ObesityMetabolic SyndromeInsulin SignalingHepatologyMetabolic Associated Steatotic Liver Disease +13

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Naoki Kumashiro, Derek M. Erion, Dongyan Zhang, +10

Proceedings of the National Academy of Sciences

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Julia Szendroedi, Toru Yoshimura, Esther Phielix, +9

Proceedings of the National Academy of Sciences

Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

Cheol Soo Choi, David B. Savage, Ameya Kulkarni, +17

Journal of Biological Chemistry

Plasma Fatty AcidsPathologyFatty Liver DiseaseInsulin SignalingMetabolic Syndrome +16

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Zheng Sun, Russell Miller, Rajesh T. Patel, +12

Nature Medicine

HepatologyBiochemistryLiver PhysiologyMetabolic RegulationMetabolism +4

Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Cheol Soo Choi, David B. Savage, Lutfi Abu-Elheiga, +11

Proceedings of the National Academy of Sciences

Caloric RestrictionInsulin SignalingOxidative StressObesityMetabolic Syndrome +16

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

Hui‐Young Lee, Cheol Soo Choi, Andreas L. Birkenfeld, +12

Cell Metabolism

Insulin ResistanceMitochondrial FunctionBiochemistryPhysiologyCatabolism +6

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Anila K. Madiraju, Yang Qiu, Rachel J. Perry, +12

Nature Medicine

Redox-dependent MechanismBiochemistryRedox RegulatorPhysiologyReactive Oxygen Specie +4