Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

Alexi Nott, P. Marc Watson, James Robinson et al. · Nature · 2008 · 425 citations

Life Sciences, Molecular Biology, Neuroscience +12

Randomized Phase II Trial Comparing Nitroglycerin Plus Vinorelbine and Cisplatin With Vinorelbine and Cisplatin Alone in Previously Untreated Stage IIIB/IV Non–Small-Cell Lung Cancer

Hiroyasu Yasuda, Mutsuo Yamaya, Katsutoshi Nakayama et al. · Journal of Clinical Oncology · 2006 · 168 citations · Full text

Medicine, Oncology, Pharmacology +10

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

Guoqiang Dong, Wei Chen, Xia Wang et al. · Journal of Medicinal Chemistry · 2017 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor

Wenwen Duan, Jin Li, Elizabeth S. Inks et al. · Journal of Medicinal Chemistry · 2015 · 88 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Novel β-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway

Yong Ling, Chenjun Xu, Lin Luo et al. · Journal of Medicinal Chemistry · 2015 · 87 citations · Full text

Medicine, Oncology, Pharmacology +17