miR-24-3p promotes colon cancer progression by targeting ING1

Abstract

Activation or upregulation of oncogenes and/or loss of function or downregulation of tumour suppressors are central to the processes involved in the transformation from normal colonic mucosa to malignant tumours. Inhibitor of growth 1 (ING1) has been functionally linked to cell cycle arrest, apoptosis and chromatin remodelling. 1 Deregulated ING1 expression is a crucial event in haematological malignancies and solid tumours, such as breast, 2 lung 3 and colorectal cancer. 4 Despite advances in identifying ING1-controlled cellular functions, ING1 regulation during colon cancer development remains largely unknown.