Inactivation of mammalian target of rapamycin (mTOR) by rapamycin in a murine model of lipopolysaccharide-induced acute lung injury. - Concepedia

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Inactivation of mammalian target of rapamycin (mTOR) by rapamycin in a murine model of lipopolysaccharide-induced acute lung injury.

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2011

Year

Lan Wang, Yao-Song Gui, Xinlun Tian, Baiqiang Cai, De-Tian Wang, Dong Zhang, He Zhao, Kai‐Feng Xu

Abstract

We confirmed that mTOR was activated during LPS-induced ALI and strongly inhibited by Rapa. Although Rapa reduced the levels of the mediators of inflammation, the overall severity and survival of the ALI murine model were unchanged.