Concepedia

A PD-1 peptide antagonist exhibits potent anti-tumor and immune regulatory activity

Huimin Tao, Lü Cheng, Lihua Liu, Hong Wang, Zhijie Jiang, Qiang Xu, Lijun Xing, Yifeng Xu, Xin-ying Cai, Jing Yao,

Cancer Letters · 2020 · 22 citations · 23 references

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyCytokines In Tumor ImmunityImmune Checkpoint InhibitorsPharmacodynamics Of ImmunotherapiesProgrammed Cell Death Ligand 1 InhibitionProgrammed Cell Death Protein 1 (Pd-1) PathwayProgrammed Death-1 InhibitionProgrammed Death-ligand 1 InhibitionProgrammed Death-ligand 1 Inhibitors

References

23

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi, Steven O’Day, David F. McDermott et al. · New England Journal of Medicine · 2010 · 15.2K citations · Full text

Medicine, Clinical Sciences, Oncology +12

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Dung T. Le, Jennifer N. Uram, Hao Wang et al. · New England Journal of Medicine · 2015 · 9.4K citations · Full text

Life Sciences, Immunology, Oncology +17

Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal · 1992 · 3.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1

Krzysztof M. Żak, Radosław Kitel, Sara Przetocka et al. · Structure · 2015 · 526 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

Suzanne I.S. Mosely, John E. Prime, Richard C.A. Sainson et al. · Cancer Immunology Research · 2016 · 423 citations

Medicine, Immunology, Oncology +16