Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, Yeming Wang, Xingwang Li et al. · The Lancet · 2020 · 51.3K citations · Full text

Virus Epidemiology, Novel Coronavirus, Covid-19 Pandemic +8

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder et al. · Cell · 2020 · 21.1K citations · Full text

Medicine, Viral Pathogenesis, Immunology +8

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta, Daniel F. McAuley, Michael Brown et al. · The Lancet · 2020 · 10K citations · Full text

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu, Lei Shi, Yijin Wang et al. · The Lancet Respiratory Medicine · 2020 · 8.8K citations · Full text

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

Inflammation, Signal Transduction, Signaling Pathway +12