Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

Sergio Serrano‐Villar, Talía Sainz, Sulggi A. Lee et al. · PLoS Pathogens · 2014 · 614 citations · Full text

Life Sciences, Immunology, Infectious Diseases +16

Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

Sine Reker Hadrup, Jan Strindhall, Tania Køllgaard et al. · The Journal of Immunology · 2006 · 470 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

Julia L. Marcus, Chun Chao, Wendy A. Leyden et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 2016 · 441 citations

Public Health, Demography, Health Sciences +15

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study

Cristina Mussini, P Lorenzini, Alessandro Cozzi‐Lepri et al. · The Lancet HIV · 2015 · 291 citations · Full text

Life Sciences, Immunology, Infectious Diseases +10

Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio

Sergio Serrano‐Villar, Maria Jesús Pérez‐Elías, Fernando Dronda et al. · PLoS ONE · 2014 · 208 citations · Full text

Public Health, Immunology, Infectious Diseases +12