ACS Infectious Diseases · 2020 · 154 citations · 22 references
PharmacyPharmacokineticsPharmacologyDrug DesignDrug DiscoveryPharmacodynamicsAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyMalariaAntimalarial AgentsAntimalarial Drug DevelopmentAntiviral TherapeuticsMedicinal HerbsPharmacokinetic Model IdentificationPharmacokinetic Property PredictionSars-cov-2 InfectionTreatment Of Malaria
of 23.17 ± 3.22 μM was not prominent among the tested compounds, lumefantrine showed therapeutic promise due to high plasma and lung drug concentrations after multiple dosing. Further mode of action analysis revealed that arteannuin B and lumefantrine acted at the post-entry step of SARS-CoV-2 infection. This research highlights the anti-SARS-CoV-2 potential of artemisinins and provides leading candidates for anti-SARS-CoV-2 drug research and development.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A Novel Coronavirus from Patients with Pneumonia in China, 2019
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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