Synthesis of 1,2-dihydro-1,3,5-triazine derivatives <i>via</i> Cu(<scp>ii</scp>)-catalyzed C(sp³)–H activation of <i>N</i>,<i>N</i>-dimethylethanolamine with amidines

Abstract

1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines and N,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process and the mechanism was proposed. This efficient synthesis of 1,2-dihydro-1,3,5-triazines was developed for the first time.