mSystems · 2020 · 88 citations · 79 references
Life SciencesInfectious DiseasesMolecular GeneticsComparative GenomicsGenomicsVirologyEmerging Viral DiseasesRespiratory InfectionsRespiratory Infectious DiseasesViral GeneticsViral GenomicsViral InfectionsEmergence Of Viral VariantsMolecular Epidemiology Of VirusesPhylogenomics Of VirusesSars-cov-2 InfectionSars-cov-2 PneumoniaSevere Acute Respiratory Syndrome
The COVID-19 pandemic continues to storm the world, with over 6.5 million cases worldwide. The severity of the disease varies with the territories and is mainly influenced by population density and age factor. In this study, we analyzed the transmission pattern of 95 SARS-CoV-2 genomes isolated from 11 different countries. Our study also revealed several nonsynonymous mutations in ORF1b and S-proteins and the impact on their structural stability. Our analysis showed the manipulation of host system by viral proteins through SARS-CoV-2-human protein interactome, which can be useful to understand the impact of virus on human health.
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Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
Paul Shannon, Andrew Markiel, Owen Ozier et al. · Genome Research · 2003 · 54.3K citations · Full text
MUSCLE: multiple sequence alignment with high accuracy and high throughput
R. C. Edgar · Nucleic Acids Research · 2004 · 46.5K citations · Full text
KEGG: Kyoto Encyclopedia of Genes and Genomes
Minoru Kanehisa · Nucleic Acids Research · 2000 · 39.2K citations · Full text