Indian <i>Trichophyton mentagrophytes</i> squalene epoxidase <i>erg1</i> double mutants show high proportion of combined fluconazole and terbinafine resistance

Abstract

The new Indian T mentagrophytes populations show several point mutations in erg1. Point mutations at position 397 were previously described and cause terbinafine resistance. A large part of the double mutants exhibit resistance to terbinafine and fluconazole, demonstrating a selective advantage of the combination of both mutations.