Concepedia

Icariin sustains the proliferation and differentiation of Aβ<sub>25-35</sub>-treated hippocampal neural stem cells via the BDNF-TrkB-ERK/Akt signaling pathway

Quan Lu, Hailing Zhu, Xuejiao Liu, Congfeng Tang

Neurological Research · 2020 · 20 citations · 24 references

DOI

Abstract

ICA promoted the proliferation and differentiation of Aβ<sub>25-35</sub>-treated hippocampal neural stem cells through BDNF-TrkB-ERK/Akt signaling pathway. The current findings might contribute to the treatment of AD.

References

24

Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

Amanda Sierra, Soraya Martín‐Suárez, Roberto Valcárcel‐Martín et al. · Cell stem cell · 2015 · 271 citations · Full text

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Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

Maria-Adelaide Micci, Balaji Krishnan, Elizabeth Bishop et al. · Molecular Neurodegeneration · 2019 · 87 citations · Full text

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology

María Díaz‐Moreno, Tomás Armenteros, Simona Gradari et al. · Proceedings of the National Academy of Sciences · 2018 · 86 citations · Full text

The antidepressant-like effects of Chaihu Shugan San: Dependent on the hippocampal BDNF-TrkB-ERK/Akt signaling activation in perimenopausal depression-like rats

Xueqin Chen, Cheng‐Fu Li · Biomedicine & Pharmacotherapy · 2018 · 69 citations

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Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease

Dongsheng Ji, Xiaming Wu, Delong Li et al. · International Journal of Biological Macromolecules · 2020 · 65 citations

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