Publication | Closed Access
On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments
32
Citations
32
References
2020
Year
Terpene SynthaseBiosynthesisBioorganic ChemistryAbsolute ConfigurationBiochemistryBiotransformationNatural SciencesBiocatalysisOphiobolin F SynthaseProduct Ophiobolin FEnzyme CatalysisMolecular BiologyNatural Product BiosynthesisIsotopic Labelling ExperimentsMicrobiologyChemical BiologyStructure-function Enzyme KineticsCyclisation Mechanism
An ophiobolin F synthase homolog was discovered from Aspergillus calidoustus CBS121601. The cyclisation mechanism of this terpene synthase was investigated by extensive isotopic labelling experiments and the absolute configuration of its product ophiobolin F was elucidated by enantioselective deuteration.
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