Concepedia

Publication | Closed Access

Chromosome Errors in Human Eggs Shape Natural Fertility Over Reproductive Life Span

DOI

13

Citations

0

References

2020

Year

Jennifer R. Gruhn, Agata P. Zielinska, Vallari Shukla, Robert Blanshard, Antonio Capalbo, Danilo Cimadomo, Dmitry Nikiforov, Andrew C. Chan, Louise Newnham, Ivan Vogel,
Obstetrical & Gynecological Survey

Abstract

(Abstracted from Science 2019;365:1466–1469) While it is understood that young females (≥13 years to early 20s) and women of advancing maternal age (AMA, mid-30s or older) have reduced fertility rates, the exact mechanisms behind this feature of the fertility curve remain unclear. Because chromosomal errors and aneuploidy cause a significant amount of pregnancy loss and congenital disorders in women of advanced maternal age, meiotic error rates throughout the entire reproductive life span may shape natural fertility.