Obstetrical & Gynecological Survey · 2020 · 14 citations · 0 references
Life SciencesGeneticsMolecular GeneticsFertilityHuman GeneticsReproductive GeneticsAneuploidyChromosomal AberrationsChromosomal AbnormalitiesChromosome AberrationsChromosome SegregationOogenesisChromosomal Segregation ErrorsChromosome Mis-segregationChromosome Segregation ErrorsFertility LimitationMeiotic Chromosome SegregationNatural FertilityOocyte AneuploidySegregation
(Abstracted from Science 2019;365:1466–1469) While it is understood that young females (≥13 years to early 20s) and women of advancing maternal age (AMA, mid-30s or older) have reduced fertility rates, the exact mechanisms behind this feature of the fertility curve remain unclear. Because chromosomal errors and aneuploidy cause a significant amount of pregnancy loss and congenital disorders in women of advanced maternal age, meiotic error rates throughout the entire reproductive life span may shape natural fertility.