Chromosome errors in human eggs shape natural fertility over reproductive life span

Jennifer R. Gruhn, Agata P. Zielinska, Vallari Shukla, +27

Science

Chromosome ErrorsFertilityGeneticsReproductive HealthGynecology +16

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates

Christian S. Ottolini, Louise Newnham, Antonio Capalbo, +13

Nature Genetics

OocyteDevelopmental BiologyFertilityChromosome SegregationMedicine +12

Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions

Alice Copsey, Shangming Tang, Philip W. Jordan, +11

PLoS Genetics

Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos

Rajiv C. McCoy, Louise Newnham, Christian S. Ottolini, +10

Human Molecular Genetics

The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I

Louise Newnham, Philip W. Jordan, Beth Rockmill, +2

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyMolecular GeneticsNonexchange ChromosomesEpigenetics +17

Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis

Philip W. Jordan, Alice Copsey, Louise Newnham, +3

Genes & Development

Crossover FormationMolecular BiologyMolecular GeneticsCytoskeletonCell Cycle +15

Monopolin Subunit Csm1 Associates with MIND Complex to Establish Monopolar Attachment of Sister Kinetochores at Meiosis I

Sourav Sarkar, Rajesh T. Shenoy, Jacob Z. Dalgaard, +4

PLoS Genetics

Same Spindle PoleGeneticsMolecular BiologyCytoskeletonCell Cycle +17

Characterization of the Escherichia coli K-12 ydhYVWXUT operon: regulation by FNR, NarL and NarP

Jonathan D. Partridge, Douglas F. Browning, Meng Xu, +5

Microbiology

K-12 Ydhyvwxut OperonYdhy Promoter RegionFnr Binding SiteBiochemistryReactive Nitrogen Specie +13

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes

Christian S. Ottolini, Antonio Capalbo, Louise Newnham, +6

Nature Protocols

Chromosome SegregationMedicineGeneticsGenome-wide RecombinationChromosome Biology +8

Ipl1/Aurora Kinase Suppresses S-CDK-Driven Spindle Formation during Prophase I to Ensure Chromosome Integrity during Meiosis

Louise Newnham, Philip W. Jordan, Jesús A. Carballo, +2

PLoS ONE

Spindle DynamicsChromatinGenome InstabilityChromosome DynamicsCell Division +13