Organocatalytic Asymmetric Fluorination of 4‐Substituted Isoxazolinones

Abstract

Abstract A straightforward method for the asymmetric fluorination of 4‐substituted isoxazolinones catalyzed by a bis‐cinchona alkaloid catalyst was developed. A series of 4‐fluoroisoxazolinone derivatives with a fluorine‐containing quaternary stereocenter were obtained in good to high yields with good enantioselectivities (up to 91 % yield, 85 % ee ).