Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Protein Function, Signal Transduction, Biochemistry +9

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Pál Pacher, Takahiro Nagayama, Partha Mukhopadhyay et al. · Nature Protocols · 2008 · 713 citations · Full text

Cardiac Function, Health Sciences, Cardiac Physiology +10

Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol.

Paul Simpson, Shoshana Savion · Circulation Research · 1982 · 452 citations

Cardiac Muscle, Heart Failure, Cardiac Progenitor Cells +20

The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells

Christine Tran Quang, Sophie Leboucher, Diana Passaro et al. · Cell Death and Disease · 2015 · 117 citations · Full text

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats

Lingling Zhao, Dawei Wu, Mengru Sang et al. · International Immunopharmacology · 2017 · 107 citations

Inflammation, Cardiovascular Disease, Lipid Peroxidation +10