Concepedia

Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell

Wahyu Widowati, Diana Krisanti Jasaputra, Sutiman Bambang Sumitro, Mochammad Aris Widodo, Tjandrawati Mozef, Rizal Rizal, Hanna Sari Widya Kusuma, Harry Murti, Indra Bachtiar, Ahmad Faried

African Health Sciences · 2020 · 69 citations · 42 references

DOIFull text

Open access

Abstract

IL-2, IL-15, and IL-18 improved activating receptors and proliferation of NK cells. IL-induced NK cells increased TNF-α, IFN-γ, PRF1 and GzmB secretion and cytotoxic activity on BC cells. High NK cell numbers increased BC cell growth inhibition.

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