Impairment of Flow-Sensitive Inwardly Rectifying K ⁺ Channels via Disruption of Glycocalyx Mediates Obesity-Induced Endothelial Dysfunction

Abstract

We conclude that obesity-induced impairment of flow-induced vasodilation is attributed to the loss of flow-sensitivity of endothelial Kir channels and propose that the latter is mediated by the biophysical alterations of the glycocalyx.