The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGF<i>β</i> Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A

Abstract

Analysis of the microarray expression profile of genes associated with TGF<i>β</i> signaling pathways has demonstrated the potential of cyclosporin A and adalimumab to induce changes in their transcriptional activity. The anti-TNF drug seems to affect TGF<i>β</i> cascades to a greater extent than cyclosporin A. The obtained results suggest that the regularity of taking the drug is important for the efficacy of psoriasis therapy.