Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 <i>in Vitro</i> Reporter Gene Assays

Abstract

The specificity analysis for measured <i>in vitro</i> effects identified whether a cytotoxicity burst had likely occurred. The SR-analysis not only prevented false positives, but it may also serve as measure for relative effect potency and can be used for quantitative <i>in vitro-in vivo</i> extrapolation and risk assessment of chemicals. https://doi.org/10.1289/EHP6664.