Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Timothy W. Bredy, Hao Wu, Cortney Crego et al. · Learning & Memory · 2007 · 544 citations · Full text

Histone Modifications, Neuropsychology, Prefrontal Cortex +21

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

Sangeeta Chawla, Peter Vanhoutte, Fiona J. L. Arnold et al. · Journal of Neurochemistry · 2003 · 307 citations

Mechanism of NMDA receptor channel block by MK-801 and memantine

Xianqiang Song, Morten Ø. Jensen, Vishwanath Jogini et al. · Nature · 2018 · 247 citations · Full text

Molecular Physiology, Biochemistry, Functional Selectivity +8

Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

Nicholas J. Porter, Adaickapillai Mahendran, Ronald Breslow et al. · Proceedings of the National Academy of Sciences · 2017 · 176 citations · Full text

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

Elena Simoni, Simona Daniele, Giovanni Bottegoni et al. · Journal of Medicinal Chemistry · 2012 · 152 citations · Full text

Multitargeted Compounds, Nmda-induced Neurotoxicity, Alzheimer ’ +19