Concepedia

Publication | Open Access

Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

DOIFull Paper Access

78

Citations

32

References

2020

Year

Hao Pan, Yuqing Lin, Jianping Dou, Zhen F. Fu, Yanqing Yao, Shanyu Ye, Saixia Zhang, Neng Wang, Aijun Liu, Xican Li,
Cell Proliferation

Abstract

Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.

References

YearCitations

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