Concepedia

Spinosin protects N2a cells from H2O2-induced neurotoxicity through inactivation of p38MAPK

Fanxing Xu, Xiaoying Zhang, Jinyu Wang, Li Xu, Bosai He, Xiao Feng, Tingxu Yan, Bo Wu, Ying Jia, Zhenzhong Wang

Journal of Pharmacy and Pharmacology · 2020 · 17 citations · 22 references

DOI

Abstract

Our findings suggest that SPI protects N2a cells from H<sub>2</sub> O<sub>2</sub> -induced oxidative damage through inactivation of p38MAPK.

References

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Wenjuan Huang, Xia Zhang, Weiwei Chen · Biomedical Reports · 2016 · 973 citations · Full text

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Alzheimer's disease: Aβ, tau and synaptic dysfunction

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Signaling pathways of bisphenol A–induced apoptosis in hippocampal neuronal cells: Role of calcium‐induced reactive oxygen species, mitogen‐activated protein kinases, and nuclear factor–κB

Soyoung Lee, Kyoungho Suk, In Kyeom Kim et al. · Journal of Neuroscience Research · 2008 · 156 citations · Full text

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

Laura Schnöder, Wenlin Hao, Yiren Qin et al. · Journal of Biological Chemistry · 2015 · 144 citations · Full text

Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors

Lulu Wang, X.-Y. Cui, S.-Y. Cui et al. · Phytomedicine · 2010 · 110 citations

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