Concepedia

A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus

Alisa K. Manning, Anton Scott Goustin, Erica L. Kleinbrink, Pattaraporn Thepsuwan, Juan Cai, Donghong Ju, Aaron Leong, Miriam S. Udler, James Bentley Brown, Mark O. Goodarzi,

Frontiers in Genetics · 2020 · 19 citations · 49 references

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Abstract

We show that the lncRNA <i>LOC157273</i> is a negative regulator of <i>PPP1R3B</i> expression and glycogen deposition in human hepatocytes and a causal transcript at an insulin-resistant T2D risk locus.

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