Direct preparation of unprotected aminimides (R₃N⁺–NH⁻) from natural aliphatic tertiary alkaloids (R₃N) by [Mn(TDCPP)Cl]-catalysed <i>N</i>-amination reaction

Abstract

A panel of natural aliphatic tertiary alkaloids (R3N) were directly converted to R3N+-NH- (without the need to prepare protected aminimides R3N+-NR'- followed by deprotection) by [Mn(TDCPP)Cl]-catalysed N-amination reaction, with O-(2,4-dinitrophenyl)hydroxylamine as the nitrogen source, in up to 98% yields under mild reaction conditions.