Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse

Abstract

The effects of SAR100842 on LPA-induced inflammation and on mechanisms linked to fibrosis like myofibroblast differentiation and Wnt pathway activation indicate that LPA₁ receptor activation plays a key role in skin fibrosis. Our results support the therapeutic potential of LPA₁ receptor antagonists in systemic sclerosis.